Development pipeline
About ACT225 BioTx
Led by world-class scientists with decades of experience in radiopharmaceutical development, antibody engineering, and clinical translation.
Leadeship team
Our leadership brings together deep expertise in radiopharmaceutical sciences, antibody engineering, and clinical translation.

Dr. Humphrey Fonge
President & CEO, ACT225 BioTx
Dr. Fonge is the President & CEO of ACT225 BioTx and a full Professor at Université Laval. He is a Canada Research Chair – Tier 1 in “Radiopharmacy and Translational Cancer Theranostics”. Dr. Fonge completed his PhD in radiopharmacy from KU Leuven (Leuven, Belgium) and postdoctoral studies from the University of Toronto (Toronto Canada). He also completed an MBA from the University of Toronto’s Rotman’s School of Business with specialization in business strategy and commercialization of life sciences innovations. His lab engages in bench to bed research of novel theranostics and has been a co-PI on four clinical trials. He has also completed informal training on many aspects of research translation including good manufacturing practice (GMP) and good clinical practice (GCP) and has several years’ experience as a scientific reviewer of Research Ethics Board (REB). Dr. Fonge is the inventor of many IPs on cancer theranostics.

Dr. Maruti Uppalapati
Chief Technology Officer, ACT225 BioTx
Dr. Uppalapati is an Assistant Professor is CTO of ACT225 BioTx and an Assistant Professor at the University of Saskatchewan. He has 15 years of experience in antibody/protein engineering and biologic drug development. During his postdoctoral work, he was one of the key scientists who developed D-protein drugs at Reflexion Pharmaceuticals, and is an inventor on several patents. As an independent researcher, his lab has constructed several phage-displayed synthetic and naive antibody (Fab and other formats) and used these libraries to generate fully-human antibodies against several cancer biomarkers of interest, with three patents filed so far. Dr. Uppalapati brings his expertise at engineering various formats of antibodies to develop stable drug candidates with optimized biodistribution and pharmacokinetics.
